| (19) |
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(11) |
EP 2 415 461 A8 |
| (12) |
CORRECTED EUROPEAN PATENT APPLICATION |
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Note: Bibliography reflects the latest situation |
| (15) |
Correction information: |
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Corrected version no 1 (W1 A1) |
| (48) |
Corrigendum issued on: |
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04.04.2012 Bulletin 2012/14 |
| (43) |
Date of publication: |
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08.02.2012 Bulletin 2012/06 |
| (22) |
Date of filing: 24.07.2010 |
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| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO SE SI SK SM TR |
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Designated Extension States: |
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BA ME RS |
| (71) |
Applicants: |
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- Roche Diagnostics GmbH
68298 Mannheim (DE)
DE
- F. Hoffmann-La Roche AG
4070 Basel (CH)
AL AT BE BG CH CY CZ DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
|
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| (72) |
Inventor: |
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- Schneider, Christian, Dr.
68165 Mannheim (DE)
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| (54) |
Stabilization of interleukin 6 in serum based solutions |
(57) In one aspect, the invention is directed to a composition comprising IL-6, an isoform
or a fragment thereof, a compound of the formula C
10 - C
18-Alkyl trimethylamonium halogenide (1), wherein the compound is saturated or unsaturated
and / or substituted or non substituted, or a salt thereof, wherein the concentration
of the compound in the composition is about 0.15 - about 0.4%, and a serum.
The present invention is further directed to a kit comprising a composition or a lyophilisate
and an instruction for use. A further embodiment of the present invention is method
of stabilizing IL-6, an isoform or a fragment thereof, comprising the steps of mixing
IL-6, an isoform or a fragment thereof, a compound of the formula C
10 - C
18-Alkyl trimethylamonium halogenide (I), wherein the compound is saturated or unsaturated
and / or substituted or non substituted, or a salt thereof, wherein the concentration
of the compound in the composition is about 0.15 - about 0.4%, and a serum.