(19)

(11)

EP 2 419 522 A2

(12)

(88) Date of publication A3: 12.05.2011 (43) Date of publication: 22.02.2012 Bulletin 2012/08 (21) Application number: 10765325.5 (22) Date of filing: 19.04.2010

(51) International Patent Classification (IPC):  C12P 21/06(2006.01) (86) International application number: PCT/US2010/031558 (87) International publication number: WO 2010/121238 (21.10.2010 Gazette 2010/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 17.04.2009 US 170260 P 10.01.2010 US 293685 P (71) Applicants: Weiss, Glen Phoenix, Arizona 85004 (US) The Translational Genomics Research Institute (TGEN) Phoenix, AZ 85004 (US)	(72) Inventor: WEISS, Glen Phoenix, Arizona 85004 (US) (74) Representative: Atkinson, Jennifer  Barker Brettell LLP 100 Hagley Road Edgbaston Birmingham B16 8QQ Edgbaston Birmingham B16 8QQ (GB)