(19)
(11) EP 2 420 179 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
21.03.2012 Bulletin 2012/12

(43) Date of publication A2:
22.02.2012 Bulletin 2012/08

(21) Application number: 11006656.0

(22) Date of filing: 12.08.2011
(51) International Patent Classification (IPC): 
A61B 3/00(2006.01)
A61B 3/117(2006.01)
A61B 5/1455(2006.01)
 A61B 3/10(2006.01)
A61B 5/00(2006.01)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 16.08.2010 US 374131 P
21.12.2010 US 425490 P
11.02.2011 EP 11001148

(71) Applicant: Neuroptix Corporation
Acton, MA 01720 (US)

(72) Inventor:
  • Hartung, Paul D.
    Acton, MA 01720 (US)

(74) Representative: Graf von Stosch, Andreas et al
Graf von Stosch Patentanwaltsgesellschaft mbH Prinzregentenstraße 22
80538 München
80538 München (DE)

   


(54) System and method for detecting amyloid proteins


(57) This invention provides a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises for example illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye previously and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.







Search report