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EP 2 421 546 A1

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(43) Date of publication: 29.02.2012 Bulletin 2012/09 (21) Application number: 09743995.4 (22) Date of filing: 16.10.2009

(51) International Patent Classification (IPC):  A61K 38/08(2006.01) A61K 38/16(2006.01) C07K 7/06(2006.01) C07K 14/005(2006.01) C07K 16/10(2006.01) G01N 33/569(2006.01) A61P 31/16(2006.01) A61K 38/10(2006.01) A61K 39/145(2006.01) C07K 7/08(2006.01) C07K 14/11(2006.01) C12Q 1/70(2006.01) G01N 33/68(2006.01) (86) International application number: PCT/US2009/061108 (87) International publication number: WO 2010/123519 (28.10.2010 Gazette 2010/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 23.04.2009 US 172115 P 23.04.2009 US 429044 23.04.2009 WO PCT/US2009/004156 07.08.2009 US 538027 08.06.2009 US 185160 P 19.05.2009 US 179686 P 25.09.2009 US 246006 P (71) Applicants: Bogoch, Samuel New York, NY 10128 (US) Bogoch, Elenore S. New York, NY 10128 (US) Bogoch, Samuel Winston Oakland, CA 94609 (US) Borsanyi, Anne Elenore Brookline, MA 02446 (US)

(72) Inventors: Bogoch, Samuel New York, NY 10128 (US) Bogoch, Elenore S. New York, NY 10128 (US) Bogoch, Samuel Winston Oakland, CA 94609 (US) Borsanyi, Anne Elenore Brookline, MA 02446 (US) (74) Representative: Friede, Thomas  Bardehle Pagenberg Prinzregentenplatz 7 81675 München 81675 München (DE)