(19)

(11)

EP 2 424 501 A2

(12)

(88) Date of publication A3: 03.03.2011 (43) Date of publication: 07.03.2012 Bulletin 2012/10 (21) Application number: 10719654.5 (22) Date of filing: 28.04.2010

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) (86) International application number: PCT/JP2010/057923 (87) International publication number: WO 2010/126168 (04.11.2010 Gazette 2010/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: AL BA ME RS (30) Priority: 30.04.2009 JP 2009111381 24.03.2010 JP 2010068625 (71) Applicant: Takeda Pharmaceutical Company Limited Osaka-shi, Osaka 541-0045 (JP)	(72) Inventors: HOSHINA, Wataru Osaka-shi Osaka 532-8686 (JP) FUKUTA, Makoto Osaka-shi Osaka 532-8686 (JP) MARUNAKA, Shigeyuki Osaka-shi Osaka 532-8686 (JP) (74) Representative: Dossmann, Gérard  Casalonga & Partners Bayerstrasse 71-73 80335 München 80335 München (DE)