(19)

(11)

EP 2 424 574 A2

(12)

(88) Date of publication A3: 10.03.2011 (43) Date of publication: 07.03.2012 Bulletin 2012/10 (21) Application number: 10718938.3 (22) Date of filing: 28.04.2010

(51) International Patent Classification (IPC):  A61K 49/04(2006.01) A61K 49/18(2006.01) (86) International application number: PCT/EP2010/055685 (87) International publication number: WO 2010/125088 (04.11.2010 Gazette 2010/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 29.04.2009 US 431884 29.04.2009 US 431892 29.04.2009 US 431899 (71) Applicant: General Electric Company Schenectady, NY 12345 (US)

(72) Inventors: COLBORN, Robert Edgar Niskayuna, NY 12309 (US) BONITATIBUS JR., Peter John Saratoga Springs, NY 12866 (US) TORRES, Andrew Soliz Troy, NY 12180 (US) MARINO, Michael Ernest Clifton Park, NY 12065 (US) BUTTS, Matthew David Rexford, NY 12148 (US) KULKARNI, Amit Schenectady NY, 12345 (US) BALES, Brian, C. Niskayuna, NY 12309 (US) HAY, Bruce Allan Niskayuna, NY 12309 (US) (74) Representative: O'Brien, Dominic Paul et al GE Healthcare Limited Pollards Wood Nightingales Lane Chalfont St Giles Buckinghamshire HP8 4SP Buckinghamshire HP8 4SP (GB)