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EP 2 427 450 A1

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(43) Date of publication: 14.03.2012 Bulletin 2012/11 (21) Application number: 10719388.0 (22) Date of filing: 27.04.2010

(51) International Patent Classification (IPC):  C07D 401/14(2006.01) C07D 491/08(2006.01) A61P 3/10(2006.01) C07D 471/04(2006.01) A61K 31/497(2006.01) (86) International application number: PCT/IB2010/051834 (87) International publication number: WO 2010/128425 (11.11.2010 Gazette 2010/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 08.05.2009 US 176528 P 02.04.2010 US 320457 P (71) Applicant: Pfizer Inc. New York, NY 10017 (US)

(72) Inventors: DAROUT, Etzer Groton, Connecticut 06340 (US) DENINNO, Michael Paul San Diego, California 92130 (US) FUTATSUGI, Kentaro Groton, Connecticut 06340 (US) GUIMARAES, Cristiano Ruch Werneck Groton, Connecticut 06340 (US) LEFKER, Bruce Allen Groton, Connecticut 06340 (US) MASCITTI, Vincent Groton, Connecticut 06340 (US) MCCLURE, Kim Francis Groton, Connecticut 06340 (US) MUNCHHOF, Michael John Groton, Connecticut 06340 (US) ROBINSON, Ralph Pelton, Jr. Groton, Connecticut 06340 (US) (74) Representative: Rudge, Andrew John  Pfizer Limited European Patent Department Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)