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(11)

EP 2 427 543 A1

(12)

(43) Date of publication: 14.03.2012 Bulletin 2012/11 (21) Application number: 10772804.0 (22) Date of filing: 05.05.2010

(51) International Patent Classification (IPC):  C12M 1/34(2006.01) (86) International application number: PCT/US2010/033801 (87) International publication number: WO 2010/129725 (11.11.2010 Gazette 2010/45)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 05.05.2009 US 175566 P 04.03.2010 US 310557 P 13.04.2010 US 323782 P (71) Applicant: Acea Biosciences, Inc. San Diego, CA 92121 (US)

(72) Inventors: WANG, Xiaobo San Diego, California 92121 (US) OUYANG, Wei San Diego, California 92121 (US) LI, Nan San Diego, California 92121 (US) XI, Biao San Diego, California 92121 (US) ABASSI, Yama A. San Diego, California 92121 (US) XU, Xiao San Diego, California 92121 (US) (74) Representative: Williams, Richard Andrew Norman  Harrison Goddard Foote 40-43 Chancery Lane GB-London WC2A 1JA GB-London WC2A 1JA (GB)