| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL
PT RO SE SI SK TR |
| (30) |
Priority: |
05.01.2007 US 878831 P
11.06.2007 US 934291 P
05.01.2007 EP 07000211
17.10.2007 EP 07020341
|
| (43) |
Date of publication of application: |
|
04.04.2012 Bulletin 2012/14 |
| (60) |
Divisional application: |
|
17169749.3 / 3239174 |
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
08700998.1 / 2099826 |
| (73) |
Proprietor: University of Zurich |
|
8006 Zurich (CH) |
|
| (72) |
Inventors: |
|
- Nitsch, Roger, Prof. Dr.
8126 Zumikon (CH)
- Hock, Christoph, Prof.
8703 Erlenbach (CH)
- Esslinger, Christoph, Dr.
8032 Zurich (CH)
- Knobloch, Marlen
1131 Tolochenaz (CH)
- Tissot, Kathrin
82061 Neuried (DE)
- Grimm, Jan, Dr.
8600 Düebendorf (CH)
|
| (74) |
Representative: Steinecke, Peter |
|
Müller Fottner Steinecke
Rechtsanwalts- und Patentanwaltspartnerschaft mbB
Römerstrasse 16 b
52428 Jülich
52428 Jülich (DE) |
| (56) |
References cited: :
EP-A- 1 172 378
WO-A-2006/103116
|
WO-A-2005/018424
|
|
| |
|
|
- GEYLIS V ET AL: "Human monoclonal antibodies against amyloid-beta from healthy adults",
NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 26, no. 5, May 2005 (2005-05), pages
597-606, XP004748495, ISSN: 0197-4580
- MASTERS C L ET AL: "AMYLOID PLAQUE CORE PROTEIN IN ALZHEIMER DISEASE AND DOWN SYNDROME",
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE,
WASHINGTON, DC; US, vol. 82, no. 12, 1 June 1985 (1985-06-01), pages 4245-4249, XP009012931,
ISSN: 0027-8424, DOI: 10.1073/PNAS.82.12.4245
- GEYLIS ET AL: "Immunotherapy of Alzheimer's disease (AD): From murine models to anti-amyloid
beta (Abeta) human monoclonal antibodies", AUTOIMMUNITY REVIEWS, ELSEVIER, AMSTERDAM,
NL, vol. 5, no. 1, January 2006 (2006-01), pages 33-39, XP005203566, ISSN: 1568-9972
- DU Y ET AL: "Human anti-beta-amyloid antibodies block beta-amyloid fibril formation
and prevent beta-amyloid-induced neurotoxicity", BRAIN, OXFORD UNIVERSITY PRESS, OXFORD,
GB, vol. 126, no. 9, September 2003 (2003-09), pages 1935-1939, XP002360367, ISSN:
0006-8950
- FRÉDÉRIQUE BARD ET AL: "Epitope and isotype specificities of antibodies to [beta]-amyloid
peptide for protection against Alzheimer's disease-like neuropathology", PROCEEDINGS
OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON,
DC; US, vol. 100, no. 4, 18 February 2003 (2003-02-18), pages 2023-2028, XP002630662,
ISSN: 0027-8424, DOI: 10.1073/PNAS.0436286100
- LEE E B ET AL: "Targeting Amyloid-beta Peptide (Abeta) Oligomers by Passive Immunization
with a Conformation-selective Monoclonal Antibody Improves Learning and Memory in
Abeta Precursor Protein (APP) Transgenic Mice", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN
SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 281, no. 7, 17 February 2006
(2006-02-17), pages 4292-4299, XP003013340, ISSN: 0021-9258, DOI: 10.1074/JBC.M511018200
|
|
