(19)
(11) EP 2 438 925 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
29.08.2012 Bulletin 2012/35

(43) Date of publication A2:
11.04.2012 Bulletin 2012/15

(21) Application number: 11170573.7

(22) Date of filing: 10.09.2004
(51) International Patent Classification (IPC): 
A61K 38/08(2006.01)
C07K 7/06(2006.01)
 A61K 38/10(2006.01)
C07K 7/08(2006.01)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

(30) Priority: 10.09.2003 US 501864 P
05.04.2004 US 559898 P
20.08.2004 US 603187 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
04788721.1 / 1663276

(71) Applicants:
  • Wyeth LLC
    Madison, NJ 07940 (US)
  • King's College London
    Strand, London WC2R 2LS (GB)

(72) Inventors:
  • Doherty, Patrick
    Twickenham, Middlesex TW1 4QR (GB)
  • Williams, Gareth
    Ilford, Essex IG1 4SG (GB)

(74) Representative: Howard, Paul Nicholas 
Carpmaels & Ransford One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

   


(54) Compounds that modulate neuronal growth and their uses


(57) Cyclic peptides and peptidomimetics are provided that bind to and/or modulate activities associated with Trk receptors, including processes associated with the growth and repair of the central nervous system (e.g., neuronal growth and survival, axonal growth, neurite outgrowth and synaptic plasticity). Cyclic peptides and peptidomimetics are also provided that block or reduce the effect of other factors that inhibit growth and/or repair of the central nervous system. Pharmaceutical compositions and other formulations comprising these compounds are provided. In addition, the invention provides methods for using the cyclic peptides and peptidomimetics to modulate Trk mediated activities, including processes such as neuronal growth, survival and recover, axonal growth, neurite outgrowth, and synaptic plasticity. Further, the invention provides methods for promoting central nervous system (CNS) neuron growth by administering a p75 receptor binding agent.







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