(19)

(11)

EP 2 440 246 A2

(12)

(88) Date of publication A3: 19.05.2011 (43) Date of publication: 18.04.2012 Bulletin 2012/16 (21) Application number: 10786502.4 (22) Date of filing: 10.06.2010

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61P 3/10(2006.01) A61P 37/00(2006.01) A61K 31/7105(2006.01) A61P 1/04(2006.01) (86) International application number: PCT/US2010/001670 (87) International publication number: WO 2010/144140 (16.12.2010 Gazette 2010/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 10.06.2009 US 185662 P (71) Applicants: University of Maryland, Baltimore Baltimore, MD 21201-1627 (US) Goldblum, Simeon Baltimore, MD 21209 (US)	(72) Inventors: FASANO, Alessio West Friendship, MD 21794 (US) LAMMERS, Karen Baltimore, MD 21231 (US) SHEA-DONOHUE, Terez Chevy Chase, MD 20815 (US) (74) Representative: Heaton, Joanne Marie  Stevens, Hewlett & Perkins 1 St. Augustine's Place Bristol BS1 4UD Bristol BS1 4UD (GB)