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EP 2 442 785 A1

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(43) Date of publication: 25.04.2012 Bulletin 2012/17 (21) Application number: 10728911.8 (22) Date of filing: 18.06.2010

(51) International Patent Classification (IPC):  A61K 8/60(2006.01) A61K 45/06(2006.01) A61K 31/7076(2006.01) A61P 17/00(2006.01) (86) International application number: PCT/JP2010/060796 (87) International publication number: WO 2010/147238 (23.12.2010 Gazette 2010/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 19.06.2009 JP 2009146051 (71) Applicant: Otsuka Pharmaceutical Co., Ltd. Tokyo 101-8535 (JP)

(72) Inventors: SHINOHARA, Shigeo Osaka-shi Osaka 541-0045 (JP) IGARASHI, Sachiyo Osaka-shi Osaka 541-0045 (JP) KAWAMURA, Mitsuaki Osaka-shi Osaka 541-0045 (JP) TANAKA, Masahiko Osaka-shi Osaka 541-0045 (JP) FURUTA, Yasuo Osaka-shi Osaka 541-0045 (JP) WAKAMATSU, Kosaburo Osaka-shi Osaka 541-0045 (JP) HARANO, Fumiki Osaka-shi Osaka 541-0045 (JP) TAKASU, Osamu Osaka-shi Osaka 541-0045 (JP) (74) Representative: HOFFMANN EITLE  Patent- und Rechtsanwälte Arabellastraße 4 81925 München 81925 München (DE)