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(11)

EP 2 443 119 A1

(12)

(43) Date of publication: 25.04.2012 Bulletin 2012/17 (21) Application number: 10727312.0 (22) Date of filing: 15.06.2010

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61K 31/4375(2006.01) C07D 498/04(2006.01) A61P 25/28(2006.01) (86) International application number: PCT/US2010/038657 (87) International publication number: WO 2010/147975 (23.12.2010 Gazette 2010/51)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 16.06.2009 US 187458 P (71) Applicant: Schering Corporation Kenilworth, NJ 07033 (US)

(72) Inventors: HUANG, Xianhai Kenilworth New Jersey 07033 (US) ZHU, Zhaoning Kenilworth New Jersey 07033 (US) GREENLEE, William, J. Kenilworth New Jersey 07033 (US) PALANI, Anandan Kenilworth New Jersey 07033 (US) ASLANIAN, Robert, G. Kenilworth New Jersey 07033 (US) (74) Representative: Buchan, Gavin MacNicol  Merck & Co., Inc. European Patent Department Hertford Road Hoddesdon, Hertfordshire EN11 9BU Hoddesdon, Hertfordshire EN11 9BU (GB)