(19)
(11) EP 2 443 229 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
26.02.2020 Bulletin 2020/09

(45) Mention of the grant of the patent:
18.12.2019 Bulletin 2019/51

(21) Application number: 10790289.2

(22) Date of filing: 18.06.2010
(51) International Patent Classification (IPC): 
C12P 17/18(2006.01)
A61K 31/4355(2006.01)
 C12N 5/04(2006.01)
(86) International application number:
PCT/US2010/039228
(87) International publication number:
WO 2010/148338 (23.12.2010 Gazette 2010/51)

(54)

Production of alkaloids by Veratrum californicum cell culture

Herstellung von Alkaloiden durch Zellkultur von Veratrum californicum

Production d'alcaloïdes par culture de cellules Veratrum californicum

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 18.06.2009 US 218178 P
25.05.2010 US 348070 P

(43) Date of publication of application:
25.04.2012 Bulletin 2012/17

(73) Proprietors:
  • Phyton Holdings, LLC
    Wilmington, Delaware 19808 (US)
  • Srinivasan, Venkatesh
    Sunnyvale, California 94087 (US)
  • Alford, Jennifer
    Ithaca, New York 14850 (US)
  • Slusar-Place, Beth
    Cortland, New York 13045 (US)
  • Swindell, Charles
    Merion, Pennsylvania 19066 (US)
  • Horn, Michael
    Noblesville, Indiana 46062 (US)
  • Alvi, Khisal
    San Diego, California 92129 (US)
  • Gorr, Gilbert
    44791 Bochum (DE)

(72) Inventors:
  • SRINIVASAN, Venkatesh
    Sunnyvale California 94087 (US)
  • ALFORD, Jennifer
    Ithaca New York 14850 (US)
  • SLUSAR-PLACE, Beth
    Cortland New York 13045 (US)
  • SWINDELL, Charles
    Merion Pennsylvania 19066 (US)
  • HORN, Michael
    Noblesville Indiana 46062 (US)
  • ALVI, Khisal
    San Diego California 92129 (US)
  • GORR, Gilbert
    44791 Bochum (DE)

(74) Representative: Lee, Nicholas John et al
Kilburn & Strode LLP Lacon London 84 Theobalds Road
London WC1X 8NL
London WC1X 8NL (GB)


(56) References cited: : 
WO-A1-2008/037732
US-A1- 2010 003 728
 US-A1- 2007 199 090
   
  • KEELER R F ET AL: "Teratogenic compounds of Veratrum californicum as a function of plant part, stage and site of growth", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 10, 1 January 1971 (1971-01-01), pages 1765-1769, XP002460031, ISSN: 0031-9422, DOI: 10.1016/S0031-9422(00)86434-1
  • GROBOSCH ET AL.: 'A toxic self-made beverage: Analytics of alkaloids from Veratrum album by LC-MS/MS.' T+K, [Online] vol. 75, no. 2, 2008, pages 63 - 67, XP008149023 Retrieved from the Internet: <URL:http://www.gtfch.org/tk/tk75_2/Grobosc h.pdf> [retrieved on 2010-07-24]
  • ZIV.: 'Bioreactor Technology for Plant Micropropagation.' HORTICULTURAL REVIEWS vol. 24, 2000, pages 1 - 30, XP008149010
  • NRUSS.: 'A New Alkaloid from Amianthium Muscaetoxicum Gray.' J. AM. CHEM. SOC. vol. 75, no. 11, 1953, pages 2772 - 2773, XP008149024
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).