(19)
(11) EP 2 445 500 A1

(12)

(43) Date of publication:
02.05.2012 Bulletin 2012/18

(21) Application number: 10737760.8

(22) Date of filing: 25.06.2010
(51) International Patent Classification (IPC): 
A61K 31/4535(2006.01)
A61K 31/553(2006.01)
A61K 45/06(2006.01)
A61K 31/337(2006.01)
 A61K 31/522(2006.01)
A61P 35/00(2006.01)
A61K 31/282(2006.01)
A61K 31/7068(2006.01)
(86) International application number:
PCT/EP2010/004119
(87) International publication number:
WO 2010/149394 (29.12.2010 Gazette 2010/52)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 25.06.2009 GB 0911042

(71) Applicant: Istituto Superiore di Sanità
00161 Roma (IT)

(72) Inventors:
  • RUGGERO, De Maria
    I-00100 Rome (IT)
  • BARTUCCI, Monica
    I-00157 Rome (IT)

(74) Representative: Robertson, James Alexander 
Marks & Clerk LLP 90 Long Acre
London WC2E 9RA
London WC2E 9RA (GB)

   


(54) COMBINATION TREATMENT OP A G2 CHECKPOINT INHIBITOR (SB-218078) AND A CHEMOTHERAPEUTIC AGENT FOR TUMORIGENIC CELLS IN SOLID TUMORS