METHOD FOR ISOLATING CIMIRACEMATE A

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EP 2 445 859 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	22.04.2015 Bulletin 2015/17

(45)	Mention of the grant of the patent:
	24.09.2014 Bulletin 2014/39

(21)	Application number: 10791704.9

(22)	Date of filing: 21.06.2010

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International Patent Classification (IPC):

C07C 39/21^(2006.01)
A61K 36/71^(2006.01)
A61K 38/47^(2006.01)

A61K 31/05^(2006.01)
A61K 36/28^(2006.01)
C07C 67/56^(2006.01)

(86)	International application number:
	PCT/IB2010/001772

(87)	International publication number:
	WO 2010/150102 (29.12.2010 Gazette 2010/52)

(54)	METHOD FOR ISOLATING CIMIRACEMATE A VERFAHREN ZUR ISOLIERUNG VON CIMIRACEMAT A PROCÉDÉ D'ISOLEMENT DU CIMIRACÉMATE A

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

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Priority:

21.06.2009 US 218962 P

(43)	Date of publication of application:
	02.05.2012 Bulletin 2012/18

(73)	Proprietors:
	BAGI Research Limited 1, Connaught Place Central Hong Kong (CN) Versitech Limited Hong Kong (CN)

(72)	Inventors:
	YANG, Lai Hung, Cindy Lam Tin Hong Kong (CN) LAU, Allan, Sy Aberdeen Hong Kong (CN)

(74)	Representative: Engelhard, Markus
	Boehmert & Boehmert Anwaltspartnerschaft mbB Patentanwälte Rechtsanwälte Pettenkoferstrasse 20-22 80336 München 80336 München (DE)

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References cited: :

WO-A1-2010/079406

HE K ET AL: "Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V, NL, vol. 1112, no. 1-2, 21 April 2006 (2006-04-21), pages 241-254, XP024967954, ISSN: 0021-9673, DOI: 10.1016/J.CHROMA.2006.01.004 [retrieved on 2006-04-21]
YANG CINDY L H ET AL: "Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages", INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) ATTACHMENT. 5. AN EVOLUTION FROM INDOLE TO AZAINDOLES LEADING TO THE DISCOVERY OF 1-(4-BENZOYLPIPERAZIN-1-YL)-2-(4,7-DIMETHO XY-1H-PYRROLO[2,3- , vol. 52, no. 21 12 November 2009 (2009-11-12), pages 6707-6715, XP009165923, ISSN: 1520-4804, DOI: 10.1021/JM9006164 Retrieved from the Internet: URL:http://pubs.acs.org/journals/jmcmar/in dex.html [retrieved on 2009-10-16]
CHEN, SHAONONG ET AL.: 'Cimiracemates A-D, phenylpropanoid esters from the rhizomes of Cimicifuga racemosa' PHYTOCHEMISTRY vol. 61, no. 4, 2002, pages 409 - 413, XP004385771
JOANNA E. BURDETTE ET AL.: '`Black Cohosh (cimicifuga racemosa L.) Protects against Menadione-Induced DNA Damage through Scavenging of Reactive Oxygen Species: Bioassay- Directed Isolation and Characterization of Active Principles' J. AGRIC. FOOD CHEM. vol. 50, no. 24, 2002, pages 7022 - 7028, XP008151984
STEFAN STROMEIER ET AL.: 'Phenolic Esters from the Rhizomes of Cimicifuga racemosa do not Cause Proliferation Effects in MCF-7 Cells' PLANTA MEDICA vol. 71, no. 6, 2005, pages 495 - 500, XP008151985

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