(19)

(11)

EP 2 446 058 A2

(12)

(88) Date of publication A3: 05.05.2011 (43) Date of publication: 02.05.2012 Bulletin 2012/18 (21) Application number: 10730125.1 (22) Date of filing: 22.06.2010

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) (86) International application number: PCT/EP2010/058782 (87) International publication number: WO 2010/149640 (29.12.2010 Gazette 2010/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 26.06.2009 WO PCT/EP2009/058059 (71) Applicant: Noviogendix Research B.V. 6525 GA Nijmegen (NL)	(72) Inventors: SMIT, Franciscus Petrus NL-6546 RN Nijmegen (NL) SCHALKEN, Jack A. NL-6524 LH Nijmegen (NL) (74) Representative: van Kooij, Adriaan et al Arnold & Siedsma Sweelickplein 1 2517 GK Den Haag 2517 GK Den Haag (NL)