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<ep-patent-document id="EP11738625B8W1" file="EP11738625W1B8.xml" lang="en" country="EP" doc-number="2449113" kind="B8" correction-code="W1" date-publ="20151125" status="c" dtd-version="ep-patent-document-v1-5">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>JDIM360 Ver 1.28 (29 Oct 2014) -  2999001/0</B007EP></eptags></B000><B100><B110>2449113</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20151125</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>11738625.0</B210><B220><date>20110725</date></B220><B240><B241><date>20110831</date></B241><B242><date>20130807</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>369549 P</B310><B320><date>20100730</date></B320><B330><ctry>US</ctry></B330><B310>10007992</B310><B320><date>20100730</date></B320><B330><ctry>EP</ctry></B330></B300><B400><B405><date>20151125</date><bnum>201548</bnum></B405><B430><date>20120509</date><bnum>201219</bnum></B430><B450><date>20151014</date><bnum>201542</bnum></B450><B452EP><date>20150706</date></B452EP><B480><date>20151125</date><bnum>201548</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C12N  15/87        20060101AFI20150519BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61K  48/00        20060101ALI20150519BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61K  47/34        20060101ALI20150519BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A61K  47/48        20060101ALI20150519BHEP        </text></classification-ipcr><classification-ipcr sequence="5"><text>A61K  39/39        20060101ALI20150519BHEP        </text></classification-ipcr><classification-ipcr sequence="6"><text>A61K  39/00        20060101ALI20150519BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>KOMPLEXIERUNG VON NUCLEINSÄUREN MIT DISULFID-VERNETZTEN KATIONISCHEN BESTANDTEILEN ZUR TRANSFEKTION UND IMMUNSTIMULATION</B542><B541>en</B541><B542>COMPLEXATION OF NUCLEIC ACIDS WITH DISULFIDE-CROSSLINKED CATIONIC COMPONENTS FOR TRANSFECTION AND IMMUNOSTIMULATION</B542><B541>fr</B541><B542>COMPLEXATION D'ACIDES NUCLÉIQUES AVEC DES COMPOSANTS CATIONIQUES RÉTICULÉS PAR DES LIAISONS DISULFURE POUR LA TRANSFECTION ET L'IMMUNOSTIMULATION</B542></B540><B560><B561><text>WO-A1-99/53961</text></B561><B561><text>WO-A1-2009/030481</text></B561><B561><text>WO-A1-2009/053700</text></B561><B561><text>WO-A1-2009/086640</text></B561><B561><text>WO-A2-01/04135</text></B561><B561><text>US-B1- 6 689 757</text></B561><B562><text>READ MARTIN L ET AL: "A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids", NUCLEIC ACIDS RESEARCH, vol. 33, no. 9, E86, May 2005 (2005-05), pages 1-16, XP002447464, DOI: :10.1093/nar/gni085 cited in the application</text></B562><B562><text>READ M L ET AL: "Vectors based on reducible polycations facilitate intracellular release of nucleic acids", JOURNAL OF GENE MEDICINE, vol. 5, no. 3, 1 March 2003 (2003-03-01), pages 232-245, XP002481542, WILEY, US ISSN: 1099-498X, DOI: 10.1002/JGM.331 cited in the application</text></B562><B562><text>MCKENZIE D L ET AL: "A potent new class of reductively activated peptide gene delivery agents", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 14, 7 April 2000 (2000-04-07), pages 9970-9977, XP002238140, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US ISSN: 0021-9258, DOI: 10.1074/JBC.275.14.9970 cited in the application</text></B562><B562><text>MCKENZIE D L ET AL: "Low molecular weight disulfide cross-linking peptides as nonviral gene delivery carriers.", BIOCONJUGATE CHEMISTRY, vol. 11, no. 6, November 2000 (2000-11), pages 901-909, XP002609379, ISSN: 1043-1802 cited in the application</text></B562><B562><text>GAO XIANG ET AL: "Nonviral gene delivery: what we know and what is next.", THE AAPS JOURNAL, vol. 9, no. 1, 2007, pages E92-104, XP002609380, ISSN: 1550-7416 cited in the application</text></B562><B562><text>HARDY JOHN G ET AL: "Synergistic effects on gene delivery--co-formulation of small disulfide-linked dendritic polycations with Lipofectamine 2000.", ORGANIC &amp; BIOMOLECULAR CHEMISTRY, vol. 7, no. 4, 21 February 2009 (2009-02-21), pages 789-793, XP002609381, ISSN: 1477-0539</text></B562><B562><text>KIM SUN HWA ET AL: "VEGF siRNA delivery system using arginine-grafted bioreducible poly(disulfide amine).", MOLECULAR PHARMACEUTICS, vol. 6, no. 3, May 2009 (2009-05), pages 718-726, XP002609382, ISSN: 1543-8384</text></B562><B562><text>TAKAE SEIJI ET AL: "PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 18, 7 May 2008 (2008-05-07), pages 6001-6009, XP002609383, ISSN: 1520-5126</text></B562><B562><text>LO ET AL: "An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection", BIOMATERIALS, vol. 29, no. 15, 4 March 2008 (2008-03-04) , pages 2408-2414, XP022526913, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2008.01.031</text></B562><B562><text>MIYATA K ET AL: "Block Catiomer Polyplexes with Regulated Densities of Charge and Disulfide Cross-Linking Directed To Enhance Gene Expression", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 126, no. 8, 3 March 2004 (2004-03-03) , pages 2355-2361, XP002993261, ISSN: 0002-7863, DOI: 10.1021/JA0379666</text></B562><B562><text>TOKUNAGA MASAKI ET AL: "Effect of oligopeptides on gene expression: comparison of DNA/peptide and DNA/peptide/liposome complexes.", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 269, no. 1, 9 January 2004 (2004-01-09), pages 71-80, XP002609384, ISSN: 0378-5173</text></B562></B560></B500><B600><B620EP><parent><cdoc><dnum><anum>15001874.5</anum></dnum><date>20150624</date></cdoc></parent></B620EP></B600><B700><B720><B721><snm>BAUMHOF, Patrick</snm><adr><str>Erlenstrasse 28</str><city>72144 Dusslingen</city><ctry>DE</ctry></adr></B721><B721><snm>VOSS, Söhnke</snm><adr><str>Savoyer Weg 12</str><city>69151 Neckarsgmünd</city><ctry>DE</ctry></adr></B721><B721><snm>KRAMPS, Thomas</snm><adr><str>Lange Gasse 44</str><city>72070 Tübingen</city><ctry>DE</ctry></adr></B721><B721><snm>KALLEN, Karl-Josef</snm><adr><str>Marienhofer Weg 24</str><city>50226 Königsdorf</city><ctry>DE</ctry></adr></B721></B720><B730><B731><snm>CureVac AG</snm><iid>101553296</iid><irf>CU01P094WOEP</irf><adr><str>Paul-Ehrlich-Str. 15</str><city>72076 Tübingen</city><ctry>DE</ctry></adr></B731></B730><B740><B741><snm>Graf von Stosch, Andreas</snm><sfx>et al</sfx><iid>101056440</iid><adr><str>Graf von Stosch 
Patentanwaltsgesellschaft mbH 
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