(19)

(11)

EP 2 454 263 A1

(12)

(43) Date of publication: 23.05.2012 Bulletin 2012/21 (21) Application number: 10800093.6 (22) Date of filing: 16.07.2010

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61K 31/519(2006.01) A61P 31/04(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/NZ2010/000148 (87) International publication number: WO 2011/008110 (20.01.2011 Gazette 2011/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 17.07.2009 US 271112 P (71) Applicants: The Albert Einstein College Of Medicine Of Yeshiva University Bronx, NY 10461 (US) Industrial Research Limited Lower Hutt (NZ)	(72) Inventors: EVANS, Gary Brian Lower Hutt (NZ) LONGSHAW, Alistair Ian Wellington (NZ) SCHRAMM, Vern L. New Rochelle New York 10805 (US) TYLER, Peter, Charles Wellington (NZ) (74) Representative: Golding, Louise Ann et al Dehns St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)