(19)

(11)

EP 2 456 469 A1

(12)

(43) Date of publication: 30.05.2012 Bulletin 2012/22 (21) Application number: 10735413.6 (22) Date of filing: 21.07.2010

(51) International Patent Classification (IPC):  A61K 47/48(2006.01) A61P 25/36(2006.01) A61P 25/04(2006.01) (86) International application number: PCT/US2010/042792 (87) International publication number: WO 2011/011543 (27.01.2011 Gazette 2011/04)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: BA ME RS (30) Priority: 21.07.2009 US 227399 P 11.09.2009 US 558395 02.06.2010 US 350853 P (71) Applicant: Nektar Therapeutics San Francisco CA 94158 (US)	(72) Inventors: RIGGS-SAUTHIER, Jennifer Huntsville AL 35802 (US) DENG, Bo-Liang Madison AL 35756 (US) RILEY, Timothy, A. Huntsville AL 35824 (US) (74) Representative: Baldock, Sharon Claire et al Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)