(19)

(11)

EP 2 459 717 A1

(12)

(43) Date of publication: 06.06.2012 Bulletin 2012/23 (21) Application number: 10739454.6 (22) Date of filing: 30.07.2010

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61K 31/713(2006.01) A61K 31/7088(2006.01) (86) International application number: PCT/US2010/043986 (87) International publication number: WO 2011/014816 (03.02.2011 Gazette 2011/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 31.07.2009 US 230453 P (71) Applicant: New York Blood Center, Inc. New York, NY 10065 (US)	(72) Inventors: CHEN, Ying Flushing NY 11354 (US) HUANG, Cheng-han Flushing NY 11354 (US) YE, Mao Woodside NY 11377 (US) (74) Representative: Wright, Andrew John  Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)