ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSKBAHRIS..MTNORS..SM..................*JJDIM360 Ver 1.28 (29 Oct 2014) - 2999001/0The file contains technical information submitted after the application was filed and not included in this specification2462147CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120150318W173deBibliographieenBibliographyfrBibliographieEP09781527.8200908052012030520130318enenen2015031820151220120613201224201411122014462014052120150318201512C07D 498/04 20060101AFI20110221BHEP C07D 498/18 20060101ALI20110221BHEP C07F 7/08 20060101ALI20110221BHEP A61K 31/4745 20060101ALI20110221BHEP A61K 31/695 20060101ALI20110221BHEP A61P 1/06 20060101ALI20110221BHEP A61P 25/24 20060101ALI20110221BHEP deKONFORMATIONSEINGESCHRÄNKTE VOLLSYNTHETSCHE MAKROCYCLISCHE VERBINDUNGENenCONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDSfrCOMPOSÉS MACROCYCLIQUES ENTIÈREMENT SYNTHÉTIQUES, À CONFORMATION CONTRAINTEEP-A2- 0 807 639WO-A2-01/77113CHEN ET AL.: "Synthesis of Novel 4-tert-Alkyl Ether Proline-Based 16- and 17-Membered Macrocyclic Compounds" J. ORG. CHEM., vol. 67, 2002, pages 2730-2733, XP002580115ARASAPPAN ET AL.: "Novel Dipeptide Macrocycles from 4-Oxo, -Thio, and -Amino-Substituted Proline Derivatives" J. ORG. CHEM., vol. 67, 2002, pages 3923-3926, XP002580116CHEN ET AL.: "NOVEL POTENT HEPATITIS C VIRUS NS3 SERINE PROTEASE INHIBITORS DERIVED FROM PROLINE-BASED MACROCYCLES" J. MED. CHEM., vol. 49, 7 January 2006 (2006-01-07), pages 995-1005, XP002447441MARSAULT ET AL.: "Discovery of a new class of macrocylic antagonists to the human motilin receptor" J. MED. CHEM., vol. 49, no. 24, 1 January 2006 (2006-01-01), pages 7190-7197, XP002484961 [retrieved on 2006-11-07]MARSAULT ET AL: "Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids" BIOORG. MED. CHEM. LETT., vol. 17, no. 15, 1 August 2007 (2007-08-01), pages 4187-4190, XP022144671ROBINSON ET AL.: "The design, structures and therapeutic potential of protein epitope mimetics" DRUG DISCOVERY TODAY, vol. 13, no. 21-22, 1 November 2008 (2008-11-01), pages 944-951, XP025574298 [retrieved on 2008-09-11]OBRECHT, DanielIm Eichacker 21CH-4112 BättwilCHERMERT, PhilippSteinbühlweg 31CH-4123 AllschwilCHOUMOUCH, Said39 rue du SoleilF-68200 MulhouseFRLACH, Franck21 rue PrincipaleF-51400 Les Grandes LogesFRLUTHER, AnatolMax-Brombacher-Weg 1079589 BinzenDEMARX, KarstenBirkenstrasse 44CH-4055 BaselCHMÖHLE, KerstinOberhausenstrasse 23CH-8907 WettswilCHPolyphor AG101257767P21865EP00Hegenheimermattweg 1254123 AllschwilCHBraun, André jr.101119090Braunpat Braun Eder AG Reussstrasse 224054 BaselCHATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTROSESISKSMTRAL20120305BA20120305RS20120305EP200906016820090805enWO20110152412011021020110620120613201224