(19)
(11) EP 2 464 225 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
23.08.2017 Bulletin 2017/34

(45) Mention of the grant of the patent:
16.09.2015 Bulletin 2015/38

(21) Application number: 10817918.5

(22) Date of filing: 17.09.2010
(51) International Patent Classification (IPC): 
C07D 311/82(2006.01)
A61K 31/35(2006.01)
 C07D 493/10(2006.01)
(86) International application number:
PCT/US2010/049341
(87) International publication number:
WO 2011/035161 (24.03.2011 Gazette 2011/12)

(54)

PROCESS FOR THE SYNTHESIS OF 4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-2',4',5'7'-TETRAIODO-3H-SPIRO[ISOBENZOFURAN-1,9'-XANTHEN]-3-ONE (ROSE BENGAL) AND RELATED XANTHENES

VERFAHREN ZUR SYNTHESE VON 4,5,6,7-TETRACHLOR-3',6'-DIHYDROXY-2',4',5'7'-TETRAIOD-3H-SPIRO-[ISOBENZOFURAN-1,9'-XANTHEN-]3-ON (BENGALROSA) UND VERWANDTEN XANTHENEN

PROCÉDÉ DE SYNTHÈSE DE 4,5,6,7-TÉTRACHLORO-3',6'-DIHYDROXY-2',4',5'7'-TÉTRAÏODO-3H-SPIRO[ISOBENZOFURAN-1,9'-XANTHEN]-3-ONE (ROSE BENGALE) ET DE XANTHÈNES APPARENTÉS

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 18.09.2009 US 243701 P

(43) Date of publication of application:
20.06.2012 Bulletin 2012/25

(73) Proprietor: Provectus Pharmaceuticals, Inc.
Knoxville, TN 37931 (US)

(72) Inventors:
  • SINGER, Jamie
    Knoxville Tennessee 37922 (US)
  • WACHTER, Eric, A.
    Oak Ridge, TN 37830 (US)
  • SCOTT, Timothy, C.
    Knoxville, TN 37932 (US)
  • LUTZ, Marlon
    Grayslake Illinois 60030 (US)
  • BABIAK, Kevin
    Evanston Illinois 60201 (US)

(74) Representative: Daniels, Jeffrey Nicholas et al
Page White & Farrer Bedford House John Street
London WC1N 2BF
London WC1N 2BF (GB)


(56) References cited: : 
WO-A1-02/05812
WO-A1-2008/003954
US-A1- 2006 257 917
US-B1- 6 335 440
US-B2- 7 504 496
 WO-A1-02/062333
US-A- 3 829 440
US-A1- 2007 292 352
US-B2- 6 303 385
   
  • J LAMBERTS ET AL: "Rose Bengal derivatives as singlet oxygen sensitizers", TETRAHEDRON, vol. 41, no. 11, 1 January 1985 (1985-01-01), pages 2183-2190, XP055053793, DOI: 10.1016/S0040-4020(01)96591-3
  • J LAMBERTS ET AL: "Novel Rose Bengal Derivatives: Synthesis and Quantum Yield Studies", J. AM. CHEM. SOC., vol. 106, no. 20, 1 January 1984 (1984-01-01), pages 5879-5883, XP055053794, DOI: 10.1021/ja00332a021
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).