(19)
(11) EP 2 467 724 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
29.10.2014 Bulletin 2014/44

(45) Mention of the grant of the patent:
23.07.2014 Bulletin 2014/30

(21) Application number: 10747657.4

(22) Date of filing: 19.08.2010
(51) International Patent Classification (IPC): 
G01N 33/68(2006.01)
(86) International application number:
PCT/GB2010/051373
(87) International publication number:
WO 2011/021041 (24.02.2011 Gazette 2011/08)

(54)

SURVIVAL PROGNOSTIC ASSAY

ÜBERLEBENSPROGNOSETEST

DOSAGE PRONOSTIQUE DE DÉTERMINATION DE LA SURVIE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 19.08.2009 GB 0914535
22.01.2010 GB 201001079

(43) Date of publication of application:
27.06.2012 Bulletin 2012/26

(60) Divisional application:
14171848.6

(73) Proprietor: The Binding Site Group Limited
Birmingham B14 4ZB (GB)

(72) Inventors:
  • MEAD, Graham Peter
    Birmingham B14 4ZB (GB)
  • BRADWELL, Arthur Randall
    Birmingham B14 4ZB (GB)

(74) Representative: Elsy, David et al
Withers & Rogers LLP 4 More London Riverside
London SE1 2AU
London SE1 2AU (GB)


(56) References cited: : 
EP-A1- 0 044 219
WO-A1-2005/103717
WO-A1-2007/125338
DE-U1-202004 012 479
EP-A1- 0 336 472
WO-A1-2006/079816
WO-A2-2010/049672
GB-B- 2 472 518
   
  • LE BRICON THIERRY ET AL: "Urinary free light chain analysis by the Freelite(R) immunoassay: A preliminary study in multiple myeloma" CLINICAL BIOCHEMISTRY, ELSEVIER INC, US, CA, vol. 35, no. 7, 1 October 2002 (2002-10-01), pages 565-567, XP008127742 ISSN: 0009-9120
  • RAJKUMAR S VINCENT ET AL: "Presence of monoclonal free light chains in serum predicts risk of progression in monoclonal gammopathy of undetermined significance (MGUS)" BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 102, no. 11, 16 November 2003 (2003-11-16), page 935A, XP008127772 ISSN: 0006-4971
  • STAGGS BRENT ET AL: "Comparison of serum quantitative free light chains (Freelite) to serum quantitative total light chains in recurrent multiple myeloma" ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, COLLEGE OF AMERICAN PATHOLOGISTS, US, vol. 128, no. 2, 1 February 2004 (2004-02-01), page 143, XP008127760 ISSN: 0363-0153
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  • HUTCHISON COLIN A ET AL: "Quantitative assessment of serum and urinary polyclonal free light chains in patients with type II diabetes: an early marker of diabetic kidney disease?" EXPERT OPINION ON THERAPEUTIC TARGETS JUN 2008 LNKD- PUBMED:18479214, vol. 12, no. 6, June 2008 (2008-06), pages 667-676, XP8132516 ISSN: 1744-7631
  • HOFMANN W ET AL: "A new concept for detection of Bence Jones proteinuria in patients with monoclonal gammopathy" CLINICAL LABORATORY, CLIN LAB PUBLICATIONS, HEIDELBERG, vol. 50, no. 3-4, 1 January 2004 (2004-01-01), pages 181-185, XP008132515 ISSN: 1433-6510
  • KYRTSONIS MARIE-CHRISTINE ET AL: "Serum free light chain ratio (FLCR) at diagnosis constitute a powerful prognostic factor of survival in multiple myeloma (MM)" BLOOD; 48TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ORLANDO,FL, USA; DECEMBER 09 -12, 2006, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 108, no. 11 part 1, 16 November 2006 (2006-11-16), pages 1-3, XP008132501 ISSN: 0006-4971
  • ROSSI JEAN-FRANCOIS ET AL: "A phase I/II study of atacicept (TACI-Ig) to neutralize APRIL and BLyS in patients with refractory or relapsed multiple myeloma (MM) or active previously treated waldenstrom's macroglobulinemia (WM)" BLOOD; 48TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ORLANDO,FL, USA; DECEMBER 09 -12, 2006, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 108, no. 11 part 1, 16 November 2006 (2006-11-16), pages 1-3, XP008132499 ISSN: 0006-4971
  • KATZMANN JERRY A ET AL: "Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: Relative sensitivity for detection of monoclonal light chains" CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, WASHINGTON, DC, vol. 48, no. 9, 1 September 2002 (2002-09-01), pages 1437-1444, XP002378160 ISSN: 0009-9147
  • ABADIE JUDE M ET AL: "Are Renal Reference Intervals Required When Screening for Plasma Cell Disorders With Serum Free Light Chains and Serum Protein Electrophoresis?" AMERICAN JOURNAL OF CLINICAL PATHOLOGY, AMERICAN SOCIETY FOR CLINICAL PATHOLOGY, US, vol. 131, no. 2, 1 February 2009 (2009-02-01), pages 166-171, XP008132506 ISSN: 0002-9173 DOI: DOI:10.1309/AJCPR2M4EUYNHLGM
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  • BRUCK P ET AL: "Lambda- and kappa-free light chains in haematologic patients" CLINICAL AND EXPERIMENTAL MEDICAL LETTERS,, vol. 49, no. 1, 1 January 2008 (2008-01-01), pages 19-22, XP008132487 ISSN: 1895-2089
  • HOPPER J E ET AL: "CLINICAL RELAPSE IN SYSTEMIC LUPUS ERYTHEMATOSUS CORRELATION WITH ANTECEDENT ELEVATION OF URINARY FREE LIGHT-CHAIN IMMUNOGLOBULIN", JOURNAL OF CLINICAL IMMUNOLOGY, vol. 9, no. 4, 1989, pages 338-350, ISSN: 0271-9142
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Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).