(19)

(11)

EP 2 470 146 A2

(12)

(88) Date of publication A3: 28.07.2011 (43) Date of publication: 04.07.2012 Bulletin 2012/27 (21) Application number: 10814298.5 (22) Date of filing: 26.08.2010

(51) International Patent Classification (IPC):  A61H 23/02(2006.01) A61H 1/00(2006.01) A61B 5/055(2006.01) (86) International application number: PCT/US2010/046792 (87) International publication number: WO 2011/028602 (10.03.2011 Gazette 2011/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 26.08.2009 US 237211 P (71) Applicant: University Of Kansas Lawrence, KS 66045-7563 (US)	(72) Inventors: BARLOW, Steven, M. Lawrence KS 66044 (US) VENKATESAN, Lalit Lawrence KS 66047 (US) (74) Representative: Rees, Kerry  Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES London EC2A 2ES (GB)