(19)
(11) EP 2 473 187 A1

(12)

(43) Date of publication:
11.07.2012 Bulletin 2012/28

(21) Application number: 10812707.7

(22) Date of filing: 30.08.2010
(51) International Patent Classification (IPC): 
A61K 39/00(2006.01)
(86) International application number:
PCT/US2010/047132
(87) International publication number:
WO 2011/026026 (03.03.2011 Gazette 2011/09)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 31.08.2009 US 238473 P
03.12.2009 US 266305 P
22.12.2009 US 644146 P
24.03.2010 US 316996 P
25.03.2010 US 731781
01.04.2010 US 752649
05.04.2010 US 754140
06.04.2010 US 754740
14.04.2010 US 323960 P

(71) Applicants:
  • Immunomedics, Inc.
    Morris Plains, NJ 07950 (US)
  • IBC Pharmaceuticals, Inc.
    Morris Plains, NJ 07950 (US)

(72) Inventors:
  • CHANG, Chien-Hsing
    Morris Plains New Jersey 07950 (US)
  • GOLDENBERG, David, M.
    Morris Plains New Jersey 07950 (US)
  • ROSSI, Edmund, A.
    Morris Plains New Jersey 07950 (US)

(74) Representative: Bohmann, Armin K. 
bohmann Anwaltssozietät Nymphenburger Strasse 1
80335 München
80335 München (DE)

   


(54) COMPOSITIONS AND METHODS OF USE OF IMMUNOTOXINS COMPRISING RANPIRNASE (RAP) SHOW POTENT CYTOTOXIC ACTIVITY