(19)
(11) EP 2 473 497 A1

(12)

(43) Date of publication:
11.07.2012 Bulletin 2012/28

(21) Application number: 10771629.2

(22) Date of filing: 02.09.2010
(51) International Patent Classification (IPC): 
C07D 333/16(2006.01)
 C07D 333/20(2006.01)
(86) International application number:
PCT/CZ2010/000099
(87) International publication number:
WO 2011/026449 (10.03.2011 Gazette 2011/10)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 02.09.2009 CZ 20090584

(71) Applicant: Zentiva, K.S.
102 37 Praha 10 (CZ)

(72) Inventors:
  • RIDVAN, Ludek
    102 00 Praha 10 (CZ)
  • CINIBULK, Josef
    190 00 Praha 9 (CZ)
  • GRUNWALDOVA, Veronika
    100 00 Praha 10 (CZ)
  • BRUSOVA, Hana
    197 00 Praha 9 (CZ)

(74) Representative: Jirotkova, Ivana 
Rott, Ruzicka & Guttmann Patent, Trademark and Law Offices Vinohradskà 37
120 00 Praha 2
120 00 Praha 2 (CZ)

   


(54) A METHOD OF CRYSTALLIZATION OF (S)-N-METHYL-3-(1-NAPHTHYLOXY)-3- (2-THIENYL)PROPYLAMINE HYDROCHLORIDE (DULOXETINE)