(19)
(11) EP 2 477 650 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
09.10.2019 Bulletin 2019/41

(45) Mention of the grant of the patent:
04.09.2019 Bulletin 2019/36

(21) Application number: 10755070.9

(22) Date of filing: 16.09.2010
(51) International Patent Classification (IPC): 
A61K 39/145(2006.01)
C12N 7/04(2006.01)
C07K 14/445(2006.01)
A61K 39/015(2006.01)
C07K 14/11(2006.01)
C12N 15/82(2006.01)
(86) International application number:
PCT/US2010/049089
(87) International publication number:
WO 2011/035004 (24.03.2011 Gazette 2011/12)

(54)

VIRUS LIKE PARTICLES COMPRISING TARGET PROTEINS FUSED TO PLANT VIRAL COAT PROTEINS

VIRUSÄHNLICHE PARTIKEL, DIE FUSIONSPROTEINE BESTEHEND AUS TARGETPROTEINEN UND COATPROTEINEN VON PFLANZENVIREN ENTHALTEN

PARTICULES DE TYPE VIRUS COMPRENANT DES PROTÉINES CIBLE FUSIONNÉES À DES PROTÉINES D'ENVELOPPE VIRALES VÉGÉTALES


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30) Priority: 25.05.2010 US 348069 P
18.09.2009 US 243774 P

(43) Date of publication of application:
25.07.2012 Bulletin 2012/30

(73) Proprietor: FRAUNHOFER USA Inc.
Newark, DE 19711-5449 (US)

(72) Inventors:
  • YUSIBOV, Vidadi
    Havertown PA 19083 (US)
  • FARRANCE, Christine, E.
    Oxford PA 19363 (US)
  • MUSIYCHUK, Konstantin, A.
    Wilmington DE 19808 (US)
  • METT, Vadim
    Newark DE 19711 (US)
  • METT, Valentina
    Newark DE 19711 (US)

(74) Representative: RatnerPrestia 
Altheimer Eck 2
80331 München
80331 München (DE)


(56) References cited: : 
WO-A1-2008/089569
US-A1- 2007 128 213
WO-A2-2007/011904
   
  • YUSIBOV V ET AL: "Peptide-based candidate vaccine against respiratory syncytial virus", VACCINE, vol. 23, no. 17-18, 18 March 2005 (2005-03-18), pages 2261-2265, XP004777535, ISSN: 0264-410X, DOI: DOI:10.1016/J.VACCINE.2005.01.039
  • SHOJI Y ET AL: "Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza", VACCINE, ELSEVIER LTD, GB, vol. 27, no. 7, 11 February 2009 (2009-02-11), pages 1087-1092, XP025898712, ISSN: 0264-410X, DOI: DOI:10.1016/J.VACCINE.2008.11.108 [retrieved on 2009-01-27] cited in the application
  • MUSIYCHUK KONSTANTIN ET AL: "A launch vector for the production of vaccine antigens in plants", INFLUENZA AND OTHER RESPIRATORY VIRUSES, BLACKWELL PUBLISHING LTD, UK, vol. 1, no. 1, 1 January 2007 (2007-01-01) , pages 19-25, XP009058889, ISSN: 1750-2640, DOI: DOI:10.1111/J.1750-2659.2006.00005.X [retrieved on 2007-01-19]
  • SAUNDERS K ET AL: "Efficient generation of cowpea mosaicvirus empty virus-like particles by the proteolytic processing of precursors in insect cells and plants", VIROLOGY, vol. 393, no. 2, 5 September 2009 (2009-09-05), pages 329-337, XP026691170, ISSN: 0042-6822, DOI: DOI:10.1016/J.VIROL.2009.08.023 [retrieved on 2009-09-05]
  • YUSIBOV V ET AL: "PURIFICATION, CHARACTERIZATION, ASSEMBLY AND CRYSTALLIZATION OF ASSEMBLED ALFALFA MOSAIC VIRUS COAT PROTEIN EXPRESSED IN ESCHERICHIA COLI", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD, GB, vol. 77, no. 4, 1 January 1996 (1996-01-01), pages 567-573, XP008021583, ISSN: 0022-1317
  • LEE L A ET AL: "Adaptations of nanoscale viruses and other protein cages for medical applications", NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE, vol. 2, no. 3, 1 September 2006 (2006-09-01), pages 137-149, XP025149635, ISSN: 1549-9634, DOI: DOI:10.1016/J.NANO.2006.07.009 [retrieved on 2006-09-01]
   
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