(19)

(11)

EP 2 480 554 A1

(12)

(43) Date of publication: 01.08.2012 Bulletin 2012/31 (21) Application number: 10755150.9 (22) Date of filing: 17.09.2010

(51) International Patent Classification (IPC):  C07D 487/18(2006.01) A61P 35/00(2006.01) A61P 29/00(2006.01) A61P 37/00(2006.01) (86) International application number: PCT/EP2010/063682 (87) International publication number: WO 2011/033053 (24.03.2011 Gazette 2011/12)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 21.09.2009 US 244216 P 12.08.2010 US 372969 P (71) Applicant: F.Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: JAHANGIR, Alam San Jose California 95148 (US) SOTH, Michael Glen Rock New Jersey 07452 (US) YANG, Hanbiao Sunnyvale California 94087 (US) LYNCH, Stephen, M. San Jose California 95118 (US) (74) Representative: Schirlin, Julien  F. Hoffmann-La Roche AG CLP - Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)