(19)

(11)

EP 2 480 573 A1

(12)

(43) Date of publication: 01.08.2012 Bulletin 2012/31 (21) Application number: 10754524.6 (22) Date of filing: 20.09.2010

(51) International Patent Classification (IPC):  C07K 16/18(2006.01) C12Q 1/68(2006.01) A61P 35/00(2006.01) C12N 15/11(2006.01) G01N 33/50(2006.01) A61P 35/04(2006.01) (86) International application number: PCT/EP2010/063802 (87) International publication number: WO 2011/036118 (31.03.2011 Gazette 2011/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 22.09.2009 EP 09170932 (71) Applicant: Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research 4058 Basel (CH)	(72) Inventors: CIOSK, Rafal CH-4125 Riehen (CH) KALCHHAUSER, Irène CH-4053 Basel (CH) (74) Representative: Favre, Nicolas  Novartis Pharma AG Patent Department 4002 Basel 4002 Basel (CH)