(19)

(11)

EP 2 480 579 A2

(12)

(88) Date of publication A3: 27.10.2011 (43) Date of publication: 01.08.2012 Bulletin 2012/31 (21) Application number: 10819481.2 (22) Date of filing: 23.09.2010

(51) International Patent Classification (IPC):  C07K 19/00(2006.01) C07K 7/08(2006.01) A61K 38/18(2006.01) C07K 7/06(2006.01) C07K 14/435(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2010/050047 (87) International publication number: WO 2011/038149 (31.03.2011 Gazette 2011/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 30.03.2010 US 319039 P 23.09.2009 US 245214 P (71) Applicant: Carolus Therapeutics, Inc. San Diego, California 92121 (US)

(72) Inventors: BERNHAGEN, Jurgen 52066 Aachen (DE) WEBER, Christian 52074 Aachen (DE) VOLLRATH, Benedikt San Diego, CA 92107 (US) TURNER, Court San Diego, CA 92127 (US) SCHULTZ, Joshua, Robert Ballston Lake, NY 12019 (US) ZERNECKE, Alma 52074 Aachen (DE) DURON, Sergio San Diego, CA 92103 (US) (74) Representative: Cole, William Gwyn et al avidity IP Merlin House Falconry Court Baker's Lane GB-Epping, Essex CM16 5DQ GB-Epping, Essex CM16 5DQ (GB)