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(11)

EP 2 482 850 A2

(12)

(88) Date of publication A3: 26.05.2011 (43) Date of publication: 08.08.2012 Bulletin 2012/32 (21) Application number: 10762838.0 (22) Date of filing: 30.09.2010

(51) International Patent Classification (IPC):  A61K 47/10(2006.01) A61K 47/38(2006.01) A61P 29/00(2006.01) A61K 47/16(2006.01) A61K 31/444(2006.01) (86) International application number: PCT/US2010/051001 (87) International publication number: WO 2011/041609 (07.04.2011 Gazette 2011/14)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR Designated Extension States: BA ME RS (30) Priority: 30.09.2009 US 247222 P (71) Applicant: Nuvo Research Inc. Mississauga, ON L4T 4H4 (CA)

(72) Inventors: BUYUKTIMKIN, Servet San Diego California 92130 (US) BUYUKTIMKIN, Nadir San Diego California 92130 (US) SINGH, Jagat Toronto Ontario M1C 4V7 (CA) NEWSAM, John M. La Jolla California 92037-7528 (US) KING-SMITH, Dominic San Diego California 92122 (US) KISAK, Edward T. San Diego California 92109 (US) GALER, Bradley S. West Chester Pennsylvania 19382 (US) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstraße 4 22607 Hamburg 22607 Hamburg (DE)