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(11)

EP 2 483 314 A1

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(43) Date of publication: 08.08.2012 Bulletin 2012/32 (21) Application number: 10768428.4 (22) Date of filing: 01.10.2010

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C07K 16/22(2006.01) A61P 35/00(2006.01) C07K 16/18(2006.01) (86) International application number: PCT/EP2010/064695 (87) International publication number: WO 2011/039370 (07.04.2011 Gazette 2011/14)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 02.10.2009 EP 09172137 03.09.2010 EP 10175316 (71) Applicant: Boehringer Ingelheim International GmbH 55216 Ingelheim am Rhein (DE)

(72) Inventors: BORGES, Eric 55216 Ingelheim Am Rhein (DE) GSCHWIND, Andreas 55216 Ingelheim Am Rhein (DE) BOUCNEAU, Joachim 9840 De Pinte (BE) DE TAVERNIER, Evelyn B-9080 Beervelde (BE) KOLKMAN, Joost B-9830 Sint-Martens-Latem (BE) MERCHIERS, Pascal B-2460 Kasterlee (BE) VAN HOORICK, Diane B-9270 Laarne (BE) (74) Representative: Hammann, Heinz et al Boehringer Ingelheim GmbH Corporate Patents Binger Strasse 173 55216 Ingelheim am Rhein 55216 Ingelheim am Rhein (DE)