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EP 2 485 730 A1

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(43) Date of publication: 15.08.2012 Bulletin 2012/33 (21) Application number: 10766200.9 (22) Date of filing: 08.10.2010

(51) International Patent Classification (IPC):  A61K 31/444(2006.01) A61K 47/12(2006.01) A61K 9/00(2006.01) A61K 47/10(2006.01) A61K 47/44(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/US2010/052111 (87) International publication number: WO 2011/044540 (14.04.2011 Gazette 2011/15)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 09.10.2009 US 250452 P (71) Applicant: Nuvo Research Inc. Mississauga, ON L4T 4H4 (CA)

(72) Inventors: BUYUKTIMKIN, Servet San Diego, California 92130 (US) BUYUKTIMKIN, Nadir San Diego, California 92130 (US) SINGH, Jagat Toronto, Ontario M1C 4V7 (CA) NEWSAM, John M. La Jolla, California 92037-7528 (US) KING-SMITH, Dominic San Diego, California 92122 (US) KISAK, Edward T. San Diego, California 92109 (US) GALER, Bradley S. West Chester, Pennsylvania 19382 (US) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)