(19)

(11)

EP 2 485 749 A1

(12)

(43) Date of publication: 15.08.2012 Bulletin 2012/33 (21) Application number: 10822481.7 (22) Date of filing: 04.10.2010

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) (86) International application number: PCT/US2010/051329 (87) International publication number: WO 2011/044044 (14.04.2011 Gazette 2011/15)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 05.10.2009 US 248681 P 23.12.2009 US 289483 P (71) Applicants: Cornell University Ithaca, NY 14850 (US) THE UNIVERSITY OF WASHINGTON Seattle, WA 98105-4608 (US)	(72) Inventors: RABINOVITCH, Peter S. Shoreline, Washington 98177 (US) DAI, Dao-Fu Seattle, Washington 98195-7705 (US) SZETO, Hazel H. New York New York 10128 (US) (74) Representative: Atkinson, Jennifer  Barker Brettell LLP 100 Hagley Road Edgbaston Birmingham B16 8QQ Edgbaston Birmingham B16 8QQ (GB)