(19)

(11)

EP 2 488 173 A1

(12)

(43) Date of publication: 22.08.2012 Bulletin 2012/34 (21) Application number: 09737509.1 (22) Date of filing: 13.10.2009

(51) International Patent Classification (IPC):  A61K 31/365(2006.01) A61K 9/20(2006.01) (86) International application number: PCT/US2009/060551 (87) International publication number: WO 2011/046546 (21.04.2011 Gazette 2011/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (71) Applicant: Teva Pharmaceutical Industries Ltd. 49131 Petah Tiqva (IL)	(72) Inventors: SILVER, David, Isaac 42490 Netanya (IL) HRAKOVSKY, Julia Rosh Ha-Ayin 48057 (IL) SOLOMONOVICH, Roey Tel Aviv 69052 (IL) ARIELI, Dafna Kadima 60920 (IL) (74) Representative: Nachshen, Neil Jacob  D Young & Co LLP 120 Holborn London EC1N 2DY London EC1N 2DY (GB)