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EP 2 488 185 A1

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(43) Date of publication: 22.08.2012 Bulletin 2012/34 (21) Application number: 10823754.6 (22) Date of filing: 16.04.2010

(51) International Patent Classification (IPC):  A61K 31/7052(2006.01) A61K 39/395(2006.01) A61K 38/16(2006.01) (86) International application number: PCT/US2010/031373 (87) International publication number: WO 2011/046634 (21.04.2011 Gazette 2011/16)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (30) Priority: 16.10.2009 WO PCT/US2009/005662 (71) Applicant: Pfizer Inc. New York, NY 10017 (US)

(72) Inventors: NITZEL, Gregory, Paul Kalamazoo, Michigan 49001 (US) ANKENBAUER, Robert, Gerard Kalamazoo, Michigan 49001 (US) CALVERT, Jay, Gregory Kalamazoo, Michigan 49001 (US) DUNYAK, Donna, Steuerwald Kalamazoo, Michigan 49001 (US) MARX, Jacqueline, Gayle Kalamazoo, Michigan 49001 (US) OIEN, Nancee, Lois Kalamazoo, Michigan 49001 (US) PEARCE, Douglas, Steven Kalamazoo, Michigan 49001 (US) STOEVA, Mira, Ivanova Kalamazoo, Michigan 49001 (US) THOMPSON, James, Richard Kalamazoo, Michigan 49001 (US) (74) Representative: Pfizer  European Patent Department 23-25 avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)