(19)

(11)

EP 2 488 251 A2

(12)

(88) Date of publication A3: 29.09.2011 (43) Date of publication: 22.08.2012 Bulletin 2012/34 (21) Application number: 10824248.8 (22) Date of filing: 18.10.2010

(51) International Patent Classification (IPC):  A61N 1/30(2006.01) C12N 13/00(2006.01) A61M 31/00(2006.01) (86) International application number: PCT/US2010/053077 (87) International publication number: WO 2011/047387 (21.04.2011 Gazette 2011/16)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 16.10.2009 US 252445 P (71) Applicant: Virginia Tech Intellectual Properties, Inc. Blacksburg, VA 24060 (US)	(72) Inventors: NEAL, Robert, E. Richmond, VA 23233 (US) GARCIA, Paulo, A. Blacksburg, VA 24060 (US) DAVALOS, Rafael, V. Blacksburg, VA 24060 (US) ROSSMEISL, John, H. Blacksburg, VA 24060 (US) ROBERTSON, John, L. Floyd, VA 24091 (US) (74) Representative: Sloboshanin, Sergej et al von Füner Ebbinghaus Finck Hano Mariahilfplatz 3 81541 München 81541 München (DE)