(19)

(11)

EP 2 490 530 A1

(12)

(43) Date of publication: 29.08.2012 Bulletin 2012/35 (21) Application number: 10825785.8 (22) Date of filing: 22.10.2010

(51) International Patent Classification (IPC):  A01N 43/04(2006.01) A61K 31/70(2006.01) (86) International application number: PCT/US2010/053848 (87) International publication number: WO 2011/050323 (28.04.2011 Gazette 2011/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 22.10.2009 US 254135 P 07.04.2010 US 321738 P 20.09.2010 US 384535 P (71) Applicant: The Washington University St. Louis, MO 63130 (US)	(72) Inventors: JANETKA, James, W. St. Louis Missouri 63130 (US) HAN, Zhenfu St. Louis Missouri 63130 (US) HULTGREN, Scott St. Louis Missouri 63130 (US) PINKNER, Jerry St. Louis Missouri 63130 (US) CUSUMANO, Corrine St. Louis Missouri 63130 (US) (74) Representative: Brewster, Andrea Ruth et al Greaves Brewster LLP Copa House Station Road Cheddar, BS27 3AH Cheddar, BS27 3AH (GB)