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(11)

EP 2 490 691 A1

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(43) Date of publication: 29.08.2012 Bulletin 2012/35 (21) Application number: 10766293.4 (22) Date of filing: 20.10.2010

(51) International Patent Classification (IPC):  A61K 31/517(2006.01) A61P 25/08(2006.01) (86) International application number: PCT/EP2010/065805 (87) International publication number: WO 2011/048150 (28.04.2011 Gazette 2011/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 20.10.2009 US 253336 P 22.07.2010 EP 10170544 (71) Applicant: Novartis AG 4056 Basel (CH)

(72) Inventors: ALLGEIER, Hans 79541 Loerrach (DE) AUBERSON, Yves CH-4002 Basel (CH) AVRAMEAS, Alexandre CH-4002 Basel (CH) BLAETTLER, Thomas CH-4460 Gelterkinden (CH) CARCACHE, David CH-4002 Basel (CH) FLOERSHEIM, Philipp CH-4002 Basel (CH) FROESTL, Wolfgang CH-1024 Ecublens (CH) GUIBOURDENCHE, Christel CH-4002 Basel (CH) KALKMAN, Hans, O. CH-4002 Basel (CH) KALLEN, Joerg CH-4002 Basel (CH) KOLLER, Manuel CH-4002 Basel (CH) LINGENHÖHL, Kurt CH-4002 Basel (CH) MA, Shenglin Shanghai 201203 (CN) MATTES, Henri CH-4002 Basel (CH) NOZULAK, Joachim CH-4002 Basel (CH) ORAIN, David CH-4002 Basel (CH) RENAUD, Johanne CH-4053 Basel (CH) STROHMAIER, Christine CH-4002 Basel (CH) (74) Representative: Hutchison, John Robert  Novartis Pharma AG Patent Department 4002 Basel 4002 Basel (CH)