(19)

(11)

EP 2 493 867 A1

(12)

(43) Date of publication: 05.09.2012 Bulletin 2012/36 (21) Application number: 10773295.0 (22) Date of filing: 28.10.2010

(51) International Patent Classification (IPC):  C07D 263/20(2006.01) A61K 31/421(2006.01) (86) International application number: PCT/EP2010/066348 (87) International publication number: WO 2011/051384 (05.05.2011 Gazette 2011/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 28.10.2009 WO PCT/EP2009/007919 23.02.2010 WO PCT/EP2010/001214 (71) Applicant: Synthon BV 6545 CM Nijmegen (NL)	(72) Inventor: WESTHEIM, Raymond Jozef Hubertus NL-6545 CM Nijmegen (NL) (74) Representative: van den Broek, Ludovicus A.G.M.  Synthon B.V. IP Research P.O. Box 7071 6503 GN Nijmegen 6503 GN Nijmegen (NL)