(19)
(11) EP 2 504 001 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
06.06.2018 Bulletin 2018/23

(45) Date of publication and mentionof the opposition decision:
21.03.2018 Bulletin 2018/12

(45) Mention of the grant of the patent:
04.03.2015 Bulletin 2015/10

(21) Application number: 10790906.1

(22) Date of filing: 25.11.2010
(51) International Patent Classification (IPC): 
A61K 31/198(2006.01)
A61P 1/02(2006.01)
A61K 31/401(2006.01)
 A61K 31/728(2006.01)
A61K 45/06(2006.01)
(86) International application number:
PCT/EP2010/068216
(87) International publication number:
WO 2011/064297 (03.06.2011 Gazette 2011/22)

(54)

COMBINATION FOR THE TREATMENT OF RADIATION- OR CHEMOTHERAPY-INDUCED MUCOSITIS

KOMBINATION ZUR BEHANDLUNG VON STRAHLUNGS- ODER CHEMOTHERAPIEBEDINGTER MUKOSITIS

COMBINAISON POUR LE TRAITEMENT D'UNE INFLAMMATION DE MUQUEUSE INDUITE PAR RAYONNEMENT OU CHIMIOTHÉRAPIE

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 26.11.2009 IT MI20092080

(43) Date of publication of application:
03.10.2012 Bulletin 2012/40

(73) Proprietor: Professional Dietetics International S.r.l. in forma abbreviata P.D. INT. S.R.L.
20129 Milano (IT)

(72) Inventors:
  • CONTI, Edoardo, Carlo, Maria
    I-20121 Milano (IT)
  • CONTI, Giovanni, Federico, Maria
    I-20121 Milano (IT)
  • ARBORIO MELLA, Isabella
    I-20121 Milano (IT)
  • DIOGUARDI, Francesco, Saverio
    I-20137 Milano (IT)

(74) Representative: Minoja, Fabrizio 
Bianchetti Bracco Minoja S.r.l. Via Plinio, 63
20129 Milano
20129 Milano (IT)


(56) References cited: : 
WO-A1-02/39978
WO-A2-2008/027904
 WO-A2-2007/048524
   
  • COLELLA G ET AL: "Efficacy of a spray compound containing a pool of collagen precursor synthetic aminoacids (l-proline, l-leucine, l-lysine and glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis: preliminary data of an open trial", INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, UNIVERSITA DEGLI STUDI DI CHIETI E PESCARA GABRIELE D'ANNUNZIO, IT, vol. 23, no. 1, 1 January 2010 (2010-01-01), pages 143-151, XP009135122, ISSN: 0394-6320
  • MARIGGIÒ M A ET AL: "Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and aminoacids", INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, UNIVERSITA DEGLI STUDI DI CHIETI E PESCARA GABRIELE D'ANNUNZIO, IT, vol. 22, no. 2, 1 April 2009 (2009-04-01), pages 485-492, XP009149561, ISSN: 0394-6320
  • FAVIA G ET AL: 'Accelerated wound healing of oral soft tissues and angiogenic effect induced by a pool of aminoacids combined to sodium hyaluronate (AMINOGRANM®)' JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS no. 2, 01 April 2008, pages 109 - 116
  • D'HONDT ET AL: 'Oral mucositis induced by anticancer treatments:' THERAPEUTICS AND CLINICAL RISK MANAGEMENT no. 2, 01 January 2006, pages 159 - 168
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).