(19)

(11)

EP 2 507 219 A2

(12)

(88) Date of publication A3: 27.10.2011 (43) Date of publication: 10.10.2012 Bulletin 2012/41 (21) Application number: 10835172.7 (22) Date of filing: 03.12.2010

(51) International Patent Classification (IPC):  C07D 273/02(2006.01) C07D 245/02(2006.01) A61K 31/549(2006.01) A61P 29/00(2006.01) C07D 285/00(2006.01) A61K 31/5395(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2010/058855 (87) International publication number: WO 2011/069045 (09.06.2011 Gazette 2011/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 03.12.2009 US 266478 P (71) Applicant: The Regents of The University of California Oakland, CA 94607-5200 (US)	(72) Inventor: PIRRUNG, Michael, C. Irvine CA 92612 (US) (74) Representative: Hill, Christopher Michael  Page White & Farrer Bedford House John Street London, WC1N 2BF London, WC1N 2BF (GB)