(19)

(11)

EP 2 509 981 A1

(12)

(43) Date of publication: 17.10.2012 Bulletin 2012/42 (21) Application number: 10799154.9 (22) Date of filing: 07.12.2010

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61P 3/00(2006.01) A61K 31/5517(2006.01) (86) International application number: PCT/US2010/059158 (87) International publication number: WO 2011/071840 (16.06.2011 Gazette 2011/24)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 10.12.2009 US 285317 P (71) Applicant: Eli Lilly and Company Indianapolis, IN 46285 (US)

(72) Inventors: ARNOLD, Macklin, Brian Indianapolis Indiana 46285 (US) BEAUCHAMP, Thomas, James Indianapolis Indiana 46285 (US) CANADA, Emily, Jane Indianapolis Indiana 46285 (US) HEMBRE, Erik, James Indianapolis Indiana 46285 (US) LU, Jianliang Indianapolis Indiana 46285 (US) RIZZO, John, Robert Indianapolis Indiana 46285 (US) SCHAUS, John, Mehnert Indianapolis Indiana 46285 (US) SHI, Qing Indianapolis Indiana 46285 (US) (74) Representative: Smith, Andrew George  Eli Lilly and Company Limited Lilly Research Centre Erl Wood Manor Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)