(19)
(11) EP 2 516 435 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.10.2014 Bulletin 2014/42

(45) Mention of the grant of the patent:
06.08.2014 Bulletin 2014/32

(21) Application number: 10800980.4

(22) Date of filing: 23.12.2010
(51) International Patent Classification (IPC): 
C07D 471/04(2006.01)
C07D 498/14(2006.01)
A61P 35/00(2006.01)
 C07D 498/04(2006.01)
A61K 31/4741(2006.01)
(86) International application number:
PCT/GB2010/002329
(87) International publication number:
WO 2011/077098 (30.06.2011 Gazette 2011/26)

(54)

INHIBITORS OF AKT ACTIVITY

INHIBITOREN DER AKT-AKTIVITÄT

INHIBITEURS D'ACTIVITÉ AKT

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 23.12.2009 GB 0922589

(43) Date of publication of application:
31.10.2012 Bulletin 2012/44

(73) Proprietor: Almac Discovery Limited
Craigavon BT63 5QD (GB)

(72) Inventors:
  • ZHANG, Lixin
    Craigavon BT63 5QD Northern Ireland (GB)
  • TREVITT, Graham, Peter
    Craigavon BT63 5QD Northern Ireland (GB)
  • MIEL, Hugues
    Craigavon BT63 5QD Northern Ireland (GB)
  • BURKAMP, Frank
    Craigavon BT63 5QD Northern Ireland (GB)
  • HARRISON, Timothy
    Craigavon BT63 5QD Northern Ireland (GB)
  • WILKINSON, Andrew, John
    Craigavon BT63 5QD Northern Ireland (GB)
  • FABRITIUS, Charles-Henry
    Craigavon BT63 5QD Northern Ireland (GB)

(74) Representative: Boult Wade Tennant 
Verulam Gardens 70 Gray's Inn Road
London WC1X 8BT
London WC1X 8BT (GB)


(56) References cited: : 
WO-A1-2009/148916
 WO-A2-2006/065601
   
  • WU Z ET AL: "Rapid assembly of diverse and potent allosteric Akt inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 18, no. 6, 15 March 2008 (2008-03-15) , pages 2211-2214, XP025695048, ISSN: 0960-894X, DOI: DOI:10.1016/J.BMCL.2007.10.023 [retrieved on 2007-10-17]
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).