(19)

(11)

EP 2 519 227 A2

(12)

(43) Date of publication: 07.11.2012 Bulletin 2012/45 (21) Application number: 10841709.8 (22) Date of filing: 30.12.2010

(51) International Patent Classification (IPC):  A61K 9/127(2006.01) A61P 25/08(2006.01) A61K 31/40(2006.01) A61P 25/00(2006.01) (86) International application number: PCT/US2010/062468 (87) International publication number: WO 2011/082283 (07.07.2011 Gazette 2011/27)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 30.12.2009 US 290903 P 30.12.2009 US 649698 (71) Applicant: Guilford, F. Timothy Palo Alto, CA 94301 (US)	(72) Inventor: Guilford, F. Timothy Palo Alto, CA 94301 (US) (74) Representative: Harrison, Scott David  Swindell & Pearson Limited 48 Friar Gate Derby DE1 1GY Derby DE1 1GY (GB)