(19)

(11)

EP 2 521 536 A2

(12)

(88) Date of publication A3: 22.03.2012 (43) Date of publication: 14.11.2012 Bulletin 2012/46 (21) Application number: 11703294.6 (22) Date of filing: 07.01.2011

(51) International Patent Classification (IPC):  A61K 9/08(2006.01) A61K 9/00(2006.01) A61K 31/485(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2011/020457 (87) International publication number: WO 2011/085158 (14.07.2011 Gazette 2011/28)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 08.01.2010 US 293227 P 07.01.2011 US 986223 (71) Applicants: Regeneron Pharmaceuticals, Inc. Tarrytown, NY 10591-6707 (US) Dix, Daniel B. Lagrangeville, NY 12540 (US) Graham, Kenneth S. Pleasant Valley, NY 12569 (US) Kamen, Douglas E. Poughquag, NY 12570 (US) Walsh, Scott M. Tarrytown, NY 10591 (US)

(72) Inventors: DIX, Daniel, B. Lagrangeville, NY 12540 (US) GRAHAM, Kenneth, S. Pleasant Valley, NY 12569 (US) KAMEN, Douglas, E. Poughquag, NY 12570 (US) WALSH, Scott, M. Tarrytown, NY 10591 (US) (74) Representative: Bentham, Andrew  J A Kemp 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)