(19)
(11) EP 2 521 795 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
08.01.2014 Bulletin 2014/02

(45) Mention of the grant of the patent:
20.11.2013 Bulletin 2013/47

(21) Application number: 11702721.9

(22) Date of filing: 07.01.2011
(51) International Patent Classification (IPC): 
C12Q 1/68(2006.01)
C12N 9/90(2006.01)
 C12N 9/12(2006.01)
(86) International application number:
PCT/US2011/020459
(87) International publication number:
WO 2011/085160 (14.07.2011 Gazette 2011/28)

(54)

MATERIALS AND METHODS FOR ISOTHERMAL NUCLEIC ACID AMPLIFICATION

MATERIALIEN UND METHODEN ZUR ISOTHERMEN AMPLIFIKATION VON NUCLEINSÄUREN

COMPOSITIONS ET PROCÉDÉS D'AMPLIFICATION ISOTHERME D'ACIDES NUCLEIQUES

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 08.01.2010 US 293372 P

(43) Date of publication of application:
14.11.2012 Bulletin 2012/46

(73) Proprietor: QIAGEN Gaithersburg, Inc.
Gaithersburg, MD 20878 (US)

(72) Inventors:
  • LOWE, Brian
    Olney Maryland 20832 (US)
  • FULBRIGHT, Anna
    Columbia Maryland 21046 (US)

(74) Representative: Roth, Carla et al
König-Szynka-Tilmann-von Renesse Patentanwälte Partnerschaft mbB Mönchenwerther Straße 11
40545 Düsseldorf
40545 Düsseldorf (DE)


(56) References cited: : 
WO-A1-2005/095654
WO-A2-2004/027025
WO-A2-2007/044671
US-A1- 2008 268 498
 WO-A1-2010/088273
WO-A2-2006/074334
WO-A2-2007/120808
   
  • MOTRE A ET AL: "Enhancing helicase-dependent amplification by fusing the helicase with the DNA polymerase", GENE, ELSEVIER, AMSTERDAM, NL, vol. 420, no. 1, 15 August 2008 (2008-08-15), pages 17-22, XP022820485, ISSN: 0378-1119, DOI: DOI:10.1016/J.GENE.2008.04.017 [retrieved on 2008-05-08]
  • GOLDMEYER JAMES ET AL: "Development of a novel one-tube isothermal reverse transcription thermophilic helicase-dependent amplification platform for rapid RNA detection.", THE JOURNAL OF MOLECULAR DIAGNOSTICS : JMD NOV 2007 LNKD- PUBMED:17975029, vol. 9, no. 5, November 2007 (2007-11), pages 639-644, XP002628183, ISSN: 1525-1578
  • YONG-JOO JEONG ET AL: "Isothermal DNA amplification in vitro: the helicase-dependent amplification system", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHÄUSER-VERLAG, BA, vol. 66, no. 20, 24 July 2009 (2009-07-24) , pages 3325-3336, XP019755988, ISSN: 1420-9071, DOI: DOI:10.1007/S00018-009-0094-3
  • AN LIXIN ET AL: "Characterization of a thermostable UvrD helicase and its participation in helicase-dependent amplification", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, vol. 280, no. 32, 13 June 2005 (2005-06-13), pages 28952-28958, XP002400121, ISSN: 0021-9258, DOI: DOI:10.1074/JBC.M503096200
   
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