(19)

(11)

EP 2 526 417 A2

(12)

(88) Date of publication A3: 01.12.2011 (43) Date of publication: 28.11.2012 Bulletin 2012/48 (21) Application number: 11735309.4 (22) Date of filing: 24.01.2011

(51) International Patent Classification (IPC):  G01N 33/48(2006.01) G01N 35/00(2006.01) G01N 27/00(2006.01) C12Q 1/25(2006.01) (86) International application number: PCT/US2011/022258 (87) International publication number: WO 2011/091363 (28.07.2011 Gazette 2011/30)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 22.01.2010 US 297515 P (71) Applicant: Bayer Healthcare LLC Tarrytown, NY 10591-5097 (US)	(72) Inventors: CHU, Amy H. Elkhart, IN 46514 (US) WARCHAL-WINDHAM, Mary Ellen Osceola, IN 46561 (US) (74) Representative: Bayer Intellectual Property GmbH  Creative Campus Monheim Alfred-Nobel-Straße 10 40789 Monheim 40789 Monheim (DE)