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(11)

EP 2 529 034 A2

(12)

(88) Date of publication A3: 17.11.2011 (43) Date of publication: 05.12.2012 Bulletin 2012/49 (21) Application number: 11737612.9 (22) Date of filing: 26.01.2011

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) C12R 1/645(2006.01) C12N 15/11(2006.01) (86) International application number: PCT/US2011/022635 (87) International publication number: WO 2011/094356 (04.08.2011 Gazette 2011/31)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR (30) Priority: 26.01.2010 US 298453 P (71) Applicants: The Translational Genomics Research Institute Phoenix, Arizona 85004 (US) Arizona Board Of Regents Acting For And On Behalf Of Northern Arizona University Flagstaff, AZ 86011-4087 (US) Liu, Cindy Flagstaff, Arizona 86001 (US) Kachur, Sergey Monterey Park, California 91754 (US) Price, Lance Flagstaff, Arizona 86001 (US)

(72) Inventors: LIU, Cindy Flagstaff Arizona 86001 (US) KACHUR, Sergey Monterey Park California 91754 (US) PRICE, Lance Flagstaff Arizona 86001 (US) (74) Representative: Kalhammer, Georg  Lederer & Keller Patentanwälte Unsöldstrasse 2 80538 München 80538 München (DE)